Faulty DNA Repair Linked to Ovarian Aging in Mice and Humans
A woman's cache of eggs drops precipitously right around her 37th birthday, but the reasons have always been puzzling. Researchers are converging on one new and eminently logical answer: The ovary's ability to repair damaged DNA may decline over time, and with it, the survival of its eggs.
Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans,Sci Transl Med